The Prognostic Significance of ALDH-۱ and SOX۹ Expression in Early Breast Cancer
Publish place: Middle East Journal of Cancer، Vol: 13، Issue: 4
Publish Year: 1401
نوع سند: مقاله ژورنالی
زبان: English
View: 54
This Paper With 12 Page And PDF Format Ready To Download
- Certificate
- من نویسنده این مقاله هستم
استخراج به نرم افزارهای پژوهشی:
شناسه ملی سند علمی:
JR_MISJ-13-4_003
تاریخ نمایه سازی: 25 آبان 1402
Abstract:
Background: Aldehyde dehydrogenase ۱ (ALDH۱) is an enzyme accountable for the detoxification of aldehydes. Sex-determining region Y-box ۹ (SOX-۹) plays a role in many biological and pathological processes. In this study, we aimed to evaluate the prognostic significance of ALDH۱ and SOX۹ expression in early breast cancer.Method: The expression of ALDH۱ and SOX-۹ was evaluated through immunohistochemistry derived from ۵۰ eligible patients with early breast cancer included in the current prospective cohort study.Results: Positive expression of ALDH۱ and SOX-۹ were detected in ۲۹ (۵۸%) and ۳۴ (۶۸%) patients, respectively. The positive expressions of both markers were statistically significant associated with increasing the stage, lymph nodes metastasis, high Ki۶۷ labeling index, and molecular subtypes (P < ۰.۰۰۱), along with with the biological markers; estrogen receptors, progesterone receptors, and human epidermal growth factor receptor ۲ over-expressions, and large tumor size (P = ۰.۰۳۹, P = ۰.۰۲۲, P = ۰.۰۲۴ and P = ۰.۰۰۳ for ALDH۱ expression and P = ۰.۰۱۲, P = ۰.۰۰۷, P = ۰.۰۰۴ , and P = ۰.۰۰۲ for SOX-۹ expression, respectively). There is a significant positive association between the expression of ALDH۱ and SOX-۹, r (correlation coefficient) = +۰.۸۰۶ (P < ۰.۰۰۱). Local recurrence was associated with the positive expression of ALDH۱ only (P = ۰.۰۴۵) and the disease progression was statistically significant and associated with the positive expression of both ALDH۱ and SOX-۹ (P = ۰.۰۳۸, P = ۰.۰۲۳, respectively). There was significant association of positive expression of SOX-۹ with reduced ۳-y disease-free survival (P = ۰.۰۳۹).Conclusion: Positive expression of ALDH-۱ and SOX۹ were associated with aggressive histopathological features and poor outcome in early breast cancer and can be considered potential prognostic markers in this group of patients.
Keywords:
Authors
Lobna Abdelaziz
Department of Clinical Oncology, Faculty of Medicine, Zagazig University, Zagazig, Egypt
Ola Harb
Department of Pathology, Faculty of Medicine, Zagazig University, Zagazig, Egypt
Abeer Abdelbary
Department of Pathology, Faculty of Medicine, Zagazig University, Zagazig, Egypt
Amrallah Mohammed
Department of Medical Oncology, Faculty of Medicine, Zagazig University, Zagazig, Egypt
Hend Elkalla
Department of Clinical Oncology and Nuclear Medicine, Faculty of Medicine, Mansoura University, Mansoura, Egypt
مراجع و منابع این Paper:
لیست زیر مراجع و منابع استفاده شده در این Paper را نمایش می دهد. این مراجع به صورت کاملا ماشینی و بر اساس هوش مصنوعی استخراج شده اند و لذا ممکن است دارای اشکالاتی باشند که به مرور زمان دقت استخراج این محتوا افزایش می یابد. مراجعی که مقالات مربوط به آنها در سیویلیکا نمایه شده و پیدا شده اند، به خود Paper لینک شده اند :