Survival Rate of Non-Epithelial Ovarian Tumors in Iran

Background: The aim of this study was to estimate the overall survival (OS) and relapse free survival (RFS) of the non-epithelial ovarian tumors (NEOTs) of ovarian germ cell tumors (OGCT) and ovarian sex cord tumors (OSCT) in Iranian women; we also evaluated the relative prognostic factors. Method: In this retrospective study, we screened the documents of all the women diagnosed with OGCTs and OSCTs from ۲۰۱۲ to ۲۰۱۹. We further assessed the OS, RFS, and different prognostic factors. Results: A statistically significant association existed between RFS and stage of the disease at diagnosis in OSCTs group by univariate analysis and multivariate analysis (HR: ۰.۲۵ (۹۵% CI (۰.۰۸-۰.۷۸), P=۰.۰۱) and multivariate analysis (HR: ۰.۲۷ (۹۵% CI (۰.۰۸-۰.۹۷), P=۰.۰۴), respectively. The kaplan-meier analysis and the Log Rrank (Mantel-Cox) showed a statistically significant relationship between the stage at diagnosis and RFS in OGCT group (P=۰.۰۴۲). RFS was ۹۶% for OGCT patients, and ۹۲.۷% for OSCT patients. During the follow-up, only one patient passed away in the dysgerminoma group; the OS rate was ۹۸% for OGCT patients, and ۱۰۰% for OSCT patients. Conclusion: The OS and RFS obtained in this study confirmed that the ovarian germ cell and sex cord malignancies were among the highly treatable solid tumors. Stage can be proposed as the main prognostic factor; also, larger series of studies are needed for detecting the prognostic significance of serum markers.

Keywords:

Survival , Ovarian Cancer , Germ cell ovarian tumor , Sex cord ovarian tumor