Phycocyanin C a Natural Product with Impressive Therapeutic Efficacy for Inhibition of Breast Tumors’ Growth and Metastasis in Vivo
Publish place: Middle East Journal of Cancer، Vol: 12، Issue: 2
Publish Year: 1400
نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:
JR_MISJ-12-2_012
تاریخ نمایه سازی: 25 آبان 1402
Abstract:
Background: Several studies have reported the anticancer effect of phycocyanin C, a natural extract isolated from the algae Arthrospira platensis. However, its therapeutic effects on the growth of breast cancer and its metastasis have not been determined yet. Method: In this case-control study, we employed phycocyanin C for the treatment of ۴T۱ breast tumor as an applicable experimental animal model for human mammary cancer and metastasis. BALB/c mice were injected subcutaneously (s.c) into the ۴th abdominal mammary fat pad with ۱×۱۰۶ ۴T۱ cells. We randomly divided the mice into two groups; one group of mice were injected with PBS as the control, and the other group was intraperitoneally injected with phycocyanin C (۸۰ mg/kg daily for ۲۰ days). Tumor growth and metastasis were assessed in both groups. Results: Phycocyanin C significantly inhibited ۴T۱ breast tumors growth (P<۰.۰۵). The mean tumors volumes at the control group were ۲.۷۳ times higher than those of the treatment group. In addition, phycocyanin C treatment could significantly inhibit the formation of metastasis colonies at vital organs like spleen, liver, and lung. Moreover, the survival rate of the tumor-bearing mice increased after about ۲۲ days by phycocyanin C treatment in comparison with the control. Conclusion: This is the first report demonstrating the anticancer effects of phycocyanin C on ۴T۱ breast tumor in vivo. Overall, our findings provided convincing evidence for the application of phycocyanin C as an anticancer therapeutic agent.
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Authors
Amirhosein Kefayat
Department of Oncology, Cancer Prevention Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
Mohadeseh Yuosefzadeh
Department of Immunology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
Parvin Goli
Department of Immunology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
Alireza Babayi
Department of Biology, Payame Noor Isfahan University, Isfahan, Iran
Abbas Rezaei
Department of Immunology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
Nafiseh Esmaeil
Department of Immunology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran