Synergistic effects of dual antimicrobial combinations of synthesized N-heterocycles or MgO nanoparticles with nisin against the growth of Aspergillus fumigatus: In vitro study
Publish place: Veterinary Research Forum، Vol: 12، Issue: 2
Publish Year: 1400
نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:
JR_VRFAN-12-2_016
تاریخ نمایه سازی: 27 آبان 1402
Abstract:
Introduction of new inhibitory agents such as peptides, heterocyclic derivatives and nanoparticles (NPs) along with preventive proceedings are effective ways to deal with standard and drug-resistant strains of microorganisms. In this regard, inhibitory activities of some recently synthesized ۴-thiazolylpyrazoles, imidazolidine- and tetrahydropyrimidine-۲-thiones and magnesium oxide (MgO) NPs alone and in combination with nisin have been assessed against Aspergillus fumigatus. Antimicrobial susceptibility tests were done via broth microdilution, disk diffusion and streak plate methods according to the modified Clinical and Laboratory Standards Institute (CLSI) guidelines. Synergistic effects were also determined as fractional inhibitory concentration (FIC) and fractional fungicidal concentration (FFC) values. Inhibitory potentials of all heterocycles and NPs against A. fumigatus were proved based on inhibition zone diameter (IZD) values in the range of ۷.۷۲ - ۱۶.۸۵ mm, minimum inhibitory concentration (MIC) values in the range of ۶۴.۰۰ - ۵۱۲ µg mL-۱ and minimum fungicidal concentration (MFC) values in the range of ۲۵۶ - ۲۰۴۸ µg mL-۱. Tetrahydropyrimidine derivative ۳f showed the best inhibitory properties. Inhibitory activity was not significant with nisin. While antifungal effects of major derivatives were improved by combination with it. The results indicated that the combined treatment of heterocycles used in the present study with nisin might be efficient for mold prevention and removal in foodstuffs or other products.
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Authors
Hamid Beyzaei
Department of Chemistry, Faculty of Science, University of Zabol, Zabol, Iran
Mojtaba Mirzaei
Young Researchers and Elite Club, Mashhad Branch, Islamic Azad University, Mashhad, Iran
Narjes Hasan Fakhrabadi
Department of Pathobiology, Faculty of Veterinary, University of Zabol, Zabol, Iran
Behzad Ghasemi
Torbat-e Jam Faculty of Medical Sciences, Torbat-e Jam, Iran
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