Implication of Plasma miR ۱۲۲ and miR ۱۵۱-۳p Levels in Diagnosis and Prognosis of Acute Coronary Syndrome Patients

Background: Acute coronary syndrome (ACS) has a significant morbidity and fatality rate. An early diagnosis and accurate prognosis are necessary. Therefore, biomarkers that are associated with coronary artery stenosis and hazard for coronary artery disease (CAD) development are far required. The objective of the current study is to identify the role of plasma miR-۱۲۲ and miR ۱۵۱-۳p as diagnostic and prognostic indicators in patients with ACS.Methods: A total of ۱۰۰ Egyptian subjects were enrolled that included ۲۵ unstable angina (UA) patients, ۲۵ NSTEMI patients, ۲۵ STEMI patients, and ۲۵ healthy volunteers. Quantitative real-time PCR (RT-PCR) for both plasma miR-۱۲۲ and ۱۵۱-۳p expression were performed and Cardiac Catheterization had been performed for displaying the severity of stenosis.Results: There was steadily significant elevation in miRNA-۱۲۲ and miR۱۵۱-۳p levels from control group to STEMI group (p<۰.۰۰۱). In studied cases, there were substantial positive correlation between both miR-۱۲۲ and miR ۱۵۱-۳p with cardiac Troponin (p<۰.۰۰۱) and coronary stenosis (p<۰.۰۰۱).Conclusion: Both miR-۱۲۲ and miR-۱۵۱ -۳p were diagnostic biomarkers for ACS and were capable of evaluation of the grade of coronary artery stenosis to expect the necessity for percutaneous coronary intervention (PCI) in medical practice. Moreover, they have prognostic value for adverse cardiac events (ACE).

Keywords:

ACS miR , ۱۲۲ miR , ۱۵۱ , ۳p NSTEMI RT , Qpcr STEMI