MIL-۱۰۱(Cr)@EDTA-Zn(II) complex as an Effective HeterogeneousCatalyst for the synthesis of polyhydroquinolines

Multicomponent reactions (MCRs) are of importance in synthetic organic chemistry as theycan produce complex molecules with greater efficacy and atom economy from three or morestarting materials in a one-step without isolation of intermediate [۱]. MCRs have been shown tobe environmentally friendly as they minimize the number of synthetic steps and workups andeliminate isolation of unstable intermediates. In addition, the synthesis of a broad range of complexproducts can be achieved by MCRs such as the Hantzsch reaction [۲]. A simple, efficient methodfor the one-pot synthesis of polyhydroquinoline derivatives via a one-pot four-component reactionof aromatic aldehydes, Ammonium acetate, ethyl acetoacetate, and dimedone in the presence of acatalytic amount of EDTA-Zn(II) complex –supported on the amine-functionalized MIL-۱۰۱(Cr)MOF in ethanol at reflux conditions is reported (Fig. ۱). The process proved to be simple,environmentally friendly, efficient and high to excellent yielding. Accordingly, the process inquestion can be given the label of "green chemistry".

Keywords:

MIL-۱۰۱(Cr)-NH۲ MOF , EDTA-Zn(II) , Post-Synthetic Modification , HantzschReaction , Polyhydroquinolines