Nanomagnetic Phosphotungstic acid-catalyzed Chemoselectivityesterification of Carbonyl bond of alpha-chloroacetic acid

Esterification of alpha-chloroacetic acid with water-soluble alcohols in the liquid phase usingsustainable methods is the first challenge in the way of the total synthesis of polymer solar cells(PSCs) [۱]. Carboxylic acid esterification is one of the basic reactions in organic chemistry, thespeed of which can be increased by increasing the acidic catalyst in the reaction medium [۲,۳]. Inthe reaction of esterification, both homogeneous and heterogeneous catalysts can be used. Amongthe heterogeneous catalysts that can be used, phosphotungstic acid stabilized on nanomagneticHercynite as a spinel normal catalytic support used to esterification alpha-chloroacetic acid withdifferent water-miscible and immiscible alcohols to prepare the corresponding esters in excellentyields, and without removing the chlorine group at the alpha position through substitutionreactions. The advantage of this is the very easy separation of the catalyst from the reactionmedium by the magnet. In fact, the application of magnetic nanoparticles in the catalysts as acatalyst base has been considered due to the good spread, the surface-to-volume ratio, the ease ofsurface modification, and the very easy and effective separation of the reaction medium.

Keywords:

Hercynite@SiO۲-PTA , Fischer Esterification , Alpha-chloroesters , Solid Acid Catalyst