Application of multi-drug chemotherapy for cancer treatment usingmagnetic CoFe۲O۴ nanoparticles

Nowadays, combination therapies are used for the treatment of cancer. Patients who usedchemotherapy; as a commonly used therapy for cancer treatment; may encounter side effects likedrug resistance. Although increasing the drug dosage led to enhancement of its therapeutic effect,some side effects like resistance of cancer cells and toxicity to normal cells will be intensified.However, considering many problems of chemotherapy, using a multidrug dosing strategy forcancer treatment increases the efficiency via synergism of used drugs and decreases drug resistanceof cancerous cells. Here, we used a combination of multi-drug chemotherapy and photothermaltherapy (PTT). We synthesized a pH-sensitive and heat-sensitive nanocomposite. Thenanocomposite exhibited some features like fibrous spherical morphology, typical mesoporousstructure, high specific surface area, narrow size distribution, excellent superparamagnetic featuresand good monodispersity. This nanocomposite, cobalt ferrite (CoFe۲O۴), has porosity andmagnetic properties that can be used for identification in MRI ([۱]). Doxorubicin hydrochloridecould be easily loaded onto the CoFe۲O۴ nanoplatforms and released with pH stimuli. Themesoporous CoFe۲O۴ core acts as T۲-weighted magnetic resonance (MR) imaging probe, PTTagent ([۲]). In this study, we loaded the drug DOX into these pores and coated it with chitosantpp,then we added ZIF-۸ layer around the synthesized NPs. ZIF-۸; a Metal Organic Framework;is a carrier for the delivery of anti-cancer drugs and a PH stimulus([۳]). After coating NPs by ZIF-۸, we load another anti-cancer drug to ZIF-۸ nanospheres. We used aptamers to target only cancercells for this nanocarrier. The size of this nanocarrier was less than ۱۰۰ nanometers after synthesisand was identified using FTIR, and drug loading was also investigated. The NPs drug delivery wasinvestigated against HT-۲۹ human colorectal adenocarcinoma cell line .

Keywords:

Multi-drug chemotherapy , Cancer , CoFe۲O۴ , Nanoparticle.