Introduction of a new DABCO-based ionic liquid as an efficient catalystfor the synthesis of benzimidazoquinazolinone derivatives
Publish place: 22nd Iranian Inorganic Chemistry Conference
Publish Year: 1402
نوع سند: مقاله کنفرانسی
زبان: English
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شناسه ملی سند علمی:
IICC22_203
تاریخ نمایه سازی: 5 آذر 1402
Abstract:
Benzimidazoquinazolinones are heterocyclic compounds that have been shown variouspharamacological activities such as anti-cancer, anti-inflammatory, anti-oxidant, antimicrobial andneuroprotective activity. The diverse pharmacological activities exhibited bybenzimidazoquinazoinone make it a promising lead compound for the development of noveltherapeutic agents. These attempts resulted in the introduction of a variety of reagents for thepromotion of the synthesis of these compounds. Although, each of these methods have their ownadvantages, some of them often suffer from one or more disadvantages such as use ofstoichiometric amounts of reagents, expensive metal precursors, tedious work-up, long reactiontimes, unsatisfactory product yields, excess of organic solvent, high temperatures, harsh reactionconditions, and difficulty in preparation of the catalyst, which limit the use of these methods.Therefore, it is important to find more convenient methods for the synthesis ofbenzimidazoquinazolinone derivatives. In this research, we have reported the preparation of a newDABCO-based ionic liquid catalyst which can be used for the promotion of the synthesis ofbenzimidazoquinazolinone derivatives. It is expected that using the mentioned dicationic ionicliquid with its remarkable features be useful for the elimination of some of the disadvantages ofthe previously reported methods [۱,۲].
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Authors
Fatemeh Mirzaei Eslamlou
Department of chemistry, Faculty of science, University of Guilan , Rasht, Iran
Maryam Mousapour
Department of chemistry, Faculty of science, University of Guilan , Rasht, Iran
Farhad Shirini
Department of chemistry, Faculty of science, University of Guilan , Rasht, Iran