Primary Intestinal Lymphangiectasia and its Association With Generalized Lymphatic Anomaly

Background: Lymph is a fluid originating in the interstitial spaces of the body that contains cells, proteins, particles, chylomicrons, and sometimes bacteria. Objectives: The aim of the present study is to demonstrate that primary intestinal lymphangiectasia (PIL) results from a disruption of lymphatic circulation, thus corresponding to a secondary rather than a primary event in the context of generalized lymphatic anomaly. Materials and Methods: In this case series and record review, an analysis of intestinal lymphatic involvement was performed on patients diagnosed with PIL between ۱۹۶۵ and ۲۰۱۳. Of the ۲۱ patients included in the study, ۱۰ had been diagnosed before ۵ years of age (۱ prenatal), ۸ between ۵ and ۱۸ years of age, and ۳ while older than ۱۸ years of age. The follow-up period varied between ۱ and ۳۴ years. Clinical data, blood and fecal parameters, imaging studies, endoscopy results, biopsy analyses, treatment details, and outcome information were collected from medical records. Endoscopy, histological studies, magnetic resonance imaging, and lymphoscintigraphy were performed on all patients. Dynamic intranodal lymphangiography was performed on ۸ patients. Results: Central lymphatic channel obstruction was identified in ۱۲ patients (۵۷%). Associated lymphatic malformation (LM) was present in ۱۶, diarrhea in ۱۰, chylothorax in ۱۱, chylous ascites in ۱۰, pericardial effusion in ۶, coagulopathy in ۳, and osteolysis in ۷. Conclusions: We consider intestinal lymphangiectasia not as an entity in itself, but as a consequence of lymphatic flow impairment in the thoracic duct, producing chylous reflux into the intestinal lymphatics.

Keywords:

Primary Intestinal lymphangiectasia , Lymphangiomatosis , Protein-Losing Enteropathy , Generalized Lymphatic Anomaly