Comparison of pulmonary function tests in patients with sickle cell anemia and sickle beta-thalassemia referring to the hematology clinic of Bandar Abbas Shahid Mohammadi Hospital with the control group in ۲۰۱۹-۲۰۲۰

Introduction: Due to the high prevalence of sickle cell anemia and beta-shaped sickle cell thalassemia in this region, we decided to conduct this study with the aim of investigating the status of pulmonary function in these patients in Bandar Abbas. Material and Methods: The statistical population in this study included all patients with sickle cell anemia and sickle cell beta-thalassemia who had referred to the hematology clinic from ۲۰۱۹-۲۰۲۰, which was equal to ۶۰ people. Also, the workers who had referred to the specialized lung clinic for periodic health tests entered the study by observing the criteria for leaving the review as a control group. Demographic information in both groups was collected in a pre-prepared checklist. Then Participants were subjected to spirometry and pulmonary volumes were measured.    Results: The patients in the case group, ۳۹ (۶۵%) were from sickle cell anemia, and ۲۱ (۳۵%) were from the sickle cell beta-thalassemia. In this study, all the studied parameters had a significant difference between the study group and the control, except for the mean age (p=۰.۹۰۶). In the control group, the values of FEV۱ (Forced expiratory volume in ۱ second), FVC (Forced vital capacity), and FEF۲۵-۷۵% (Forced expiratory flow ۲۵-۷۵%) are higher than these values in the case group, and this difference is significant (P <۰.۰۰۱). Conclusion: The results of the present study showed that the levels of FEV۱, FVC and FEF ۲۵-۷۵% in the control group are higher than these values in the patient group and this difference is significant.

Keywords:

Sickle cell anemia , Sickle cell beta-thalassemia , Pulmonary complications , Spirometry