Idiopathic Granulomatous Mastitis: Diagnosis and Histopathologic Features
Publish place: Archives of Breast Cancer، Vol: 9، Issue: 0
Publish Year: 1401
نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:
JR_ARCHB-9-0_004
تاریخ نمایه سازی: 14 آذر 1402
Abstract:
Background: Idiopathic granulomatous mastitis (IGM) is a rare benign inflammatory breast condition, mostly affecting women of reproductive age within a few years of pregnancy. Due to diverse clinical and radiologic features, IGM can mimic a vast spectrum of breast conditions. Therefore, histological findings are one of the most essential bases of diagnosis.
Methods: A literature search was performed to review the characteristics of IGM with an emphasis on histopathological features in English sources from ۲۰۱۰ to ۲۰۲۲. The key words used for PubMed database search were “breast”, “granulomatous mastitis”, “histopathology”, and “pathology.”
Results: In total, ۱۹۲ articles were retrieved, from which ۳۸ most relevant manuscripts were selected for this review article.
Conclusion: The diagnosis of IGM depends on clinical, radiologic, and pathologic findings. Palpable mass is the most frequent complaint. An irregular hypoechoic mass with varying degrees of posterior phenomena is the most common sonographic finding. Histologically, IGM is characterized by a non-caseating lobulocentric granulomatous inflammation; composed of tight aggregates of epithelioid histiocytes with or without multinucleated giant cells. At times, the presence of cystic empty vacuoles lined by neutrophils is noted that is commonly associated with cystic neutrophilic granulomatous mastitis (CNGM), a variant of IGM. Atypical findings for IGM includes: The presence of atypia and/or malignancy, caseous necrosis, marked eosinophilic infiltration, absence of granulomatous inflammation, etc.
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Authors
Kiana Anousha
Cancer institute, Pathology Department, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences
Maryam Azizi
Cancer institute, Pathology Department, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences
Vahid Soleimani
Cancer institute, Pathology Department, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences
Amin Rezvani
Cancer institute, Pathology Department, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences