Eco-Friendly Synthesis, Characterization, and Antimicrobial Study of Chitosan/Bi (OH)۳ Nanocomposites
Publish Year: 1402
نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:
JR_JCMI-10-1_004
تاریخ نمایه سازی: 14 آذر 1402
Abstract:
Background: Nowadays, antimicrobial resistance is one of the most important concerns caused by the
extensive use of antibiotics. Efforts to find new materials with antimicrobial effects have been continued
more seriously than before. Nanoparticles (NPs) with very small dimensions and extraordinary properties
have the potential to overcome antimicrobial resistance, so the use of previous antimicrobial substances at
the nanometer dimensions to investigate physicochemical and antimicrobial effects could help overcome
these universal concerns.
Methods: In this study, NPs were synthesized by hydrothermal-assisted microwave technique. Scanning
electron microscopy (SEM), dynamic light scattering (DLS), and atomic force microscopy (AFM) were
carried out to investigate the physicochemical properties. Further, energy dispersive spectroscopy and
Fourier-transform infrared spectroscopy analyses were carried out to analyze the chemical composition of
nanocomposites. Then, their minimum inhibitory concentration was measured on seven bacterial isolates.
Results: The majority of NPs were in the range of ۴۰-۱۰۰ nanometers which is the well-optimized size
for our purpose. Antimicrobial analysis revealed the effect of synthesized nanocomposites on every seven
microbial isolates, including three gram-positive isolates (i.e., Staphylococcus aureus, Micrococcus luteus,
Bacillus subtilis) and four gram-negative isolates (i.e., Serratia marcescens, Escherichia coli, Pseudomonas
aeruginosa, Klebsiella pneumoniae).
Conclusion: Synthesized nanocomposite revealed a good antimicrobial effect on all bacterial isolates. It is
suggested to investigate the cellular toxicity of synthesized nanocomposite in the next studies.
Keywords:
Authors
Fatemeh Mehrabi
Pharmaceutics Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran
Mohammad Hasan Moshafi
Pharmaceutics Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran
Sina Bahraminejad
Pharmaceutics Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran
Mehdi Ranjbar
Pharmaceutics Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran