Comparison of Analgesic Effect of Agnogol with Mefenamic Acid in the Treatment of Primary Dysmenorrhea

Background and Objective: Primary dysmenorrhea is one of the most common complaints among women in reproductive age in that about half of young women suffer from dysmenorrhea. Nowadays, many people have a tendency to use a traditional medicine for dysmenorrhea. Hence, we aimed to compare the analgesic effect of Agnogol and Mefenamic acid in the treatment of primary dysmenorrhea.  Material and Methods: This clinical trial was conducted on ۴۴ women with primary dysmenorrhea referred to Hajar hospital in Shahrekord. The participants were randomly allocated to two groups of Agnogol (n=۲۳) to use one ۳.۲ mg Agnogol pill for three times a day and Mefenamic Acid (n=۲۱) to use ۲۵۰ mg Mefenamic acid every ۸ hours a day for three days. The pain severity was detected by Visual Analogue Scale. We used Independent and Paired t test for comparing the means of quantitative variables and Chi Square for qualitative variables ( P<۰.۰۵ ).  Results: Considering age, menstrual duration, menstrual interval, and pain severity score, there was no significant difference in two groups at the beginning of the study (P>۰.۰۵). After intervention, a significant reduction was found in the mean of pain score over time in both Agnogol (P<۰.۰۰۱) and Mefenamic acid (P۰.۰۵).  Conclusion: Given the same effect of Agnogol in mitigating dysmenorrhea, we recommend it as an appropriate alternative for Mefenamic acid.

Keywords:

Agnogol , dysmenorrhea , Mefenamic acid , آگنوگل , دیسمنوره اولیه , مفنامیک اسید