Improved anorgasmia following add-on lamotrigine treatment

Sexual dysfunction is common after using antiepileptic drugs, and anorgasmia can occur as a treatment-emergent adverse event. The positive effect of lamotrigine on improving anorgasmia in epilepsy patients has been reported in a few studies. Anorgasmia is a common manifestation in epileptic patients . Anorgasmia or ejaculation without achieving orgasm is permanent or recurrent, happening despite adequate stimulation.The current paper presents a ۳۱-year-old male with epilepsy since early childhood who received carbamazepine and phenobarbital. He experienced anorgasmia, and by switching to valproate sodium, the seizures, and anorgasmia were somewhat improved. But both problems were completely resolved after receiving lamotrigine. An ۱۸-month follow-up of the patient did not reveal any particular issue. Lamotrigine is recommended alongside other antiepileptic drugs in patients who have cure-induced anorgasmia.Considering both the improvement of anorgasmia and reduced number of seizures, long-term follow-up is recommended in which lamotrigine alongside other antiepileptic drugs is suggested in the treatment of patients with anorgasmia.

Keywords:

Epilepsy , Sexual Dysfunction , anorgasmia , lamotrigine