Simultaneous Effect of Atorvastatin and Combined Training on lipid and hepatic enzymes in Rats induced Non-Alcoholic Fatty Liver Disease

Introduction: Non-alcoholic fatty liver disease (NAFLD) is one of the most common liver diseases, the prevalence of which is increasing. This study aimed to evaluate the effect of atorvastatin and combined training in NAFLD-induced rats. Methods: This study was conducted on ۲۱ male Wistar rats, divided into two groups: ۱) HFFD + combined training + atorvastatin and ۲) HFFD + atorvastatin. The groups received HFFD for ۱۵ weeks to induce NAFLD. Atorvastatin was administrated at the dose of ۲mg/kg/day. The interventions (atorvastatin and combined training) were performed for eight weeks. Results: Alanine transaminase (ALT) was significantly reduced, and high-density lipoprotein (HDL) was increased in the HFFD + atorvastatin group. Low-density lipoprotein (LDL) decreased significantly in the HFFD + combined training + atorvastatin. There was no significant difference in the aspartate transaminase (AST), triglyceride (TG), alkaline phosphatase (ALP), and weight between the groups. Conclusion: Based on the findings, Atorvastatin, along with combined training, improved NAFLD. Therefore, they can be used to reduce the complications of NAFLD. However, more studies are needed to confirm the results.

Keywords:

Atorvastatin , High-Fat-Fructose diet , Non-alcoholic fatty liver disease , Combined training