Vitamin D and miRNA-۱۵۵ in Behçet’s Disease: Possible Association with the Disease and Disease Activity
Publish Year: 1402
نوع سند: مقاله ژورنالی
زبان: English
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JR_RBMB-12-2_005
تاریخ نمایه سازی: 4 دی 1402
Abstract:
Background: Vitamin D (vit D) controls inflammation and immunity. In Behçet’s disease (BD), microRNA-۱۵۵ is recognized as a significant immune response regulator. We aimed to investigate the role of vit D on immunomodulation and downregulation of inflammatory pathways associated with BD and detect the role of miRNA-۱۵۵ in BD.
Methods: miRNA-۱۵۵ expression by Real Time -Polymerase Chain Reaction (RT-PCR), and vit D, nuclear factor Kappa-light-chain-enhancer of activated B cells (NF-κB), and Tumor necrosis fact of TNF-α) expression by Enzyme Linked Immunosorbent Assay (ELISA) were assessed.
Results: BD patients had a significantly higher relative expression of microRNA-۱۵۵ (P< ۰.۰۰۱), it was significantly related to vascular manifestations (P< ۰.۰۰۱). Vit D relative expression was significantly low in BD (P< ۰.۰۰۱). There was a significant rise in miRNA-۱۵۵ in the active group compared to the inactive group (P< ۰.۰۰۱). A significant decrease in vit D levels (IU) was found in inactive and active individuals suffering from BD when compared to controls (P< ۰.۰۰۱). A significant rise was found in vit D levels in inactive BD cases (P< ۰.۰۰۱). A significant positive correlations were found between miRNA-۱۵۵, NF-κB, TNF-α, and negative correlations with vit D relative expression in BD patients.
Conclusions: miRNA-۱۵۵ relative expression is higher in BD is significantly related to vascular manifestations. It may have a relationship to disease activity. Vitamin D relative expression is significantly low in BD patients, which can significantly influence immunomodulatory BD therapy. Vitamin D deficiency linked to active BD.
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Authors
Dina Mohamed Mekawy
Medical Biochemistry & Molecular Biology, Faculty of Medicine, Cairo University, Egypt & Medical Biochemistry and Molecular Biology, Faculty of Medicine, Badr University, Egypt.
Mervat Eissa
Rheumatology Department, Faculty of Medicine, Cairo University, Egypt.
Noha Adly Sadik
Internal medicine Faculty of Medicine, Cairo University, Egypt.
Rana Mohamed Abd-Elrahman
Medical Biochemistry & Molecular Biology, Faculty of Medicine, Cairo University, Egypt.
Ahmed Fawzy
Medical Physiology, Faculty of Medicine, Cairo University, Egypt.
Marwa Fathy Amer
Medical Biochemistry & Molecular Biology, Faculty of Medicine, Cairo University, Egypt.
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