Pharmaceutical Characterization and in vivo Evaluation of the Possible Anti-Inflammatory Effect of Topical Allopurinol Gel in an Animal Model

Dermatitis, like inflammation, is a group of common dermatological symptoms and may be associated with systemic and skin diseases. The objective of the current study is to evaluate the potential anti-inflammatory effect of the topical allopurinol against inflammation like skin dermatitis induced by۱-isobutyl-۱H-imidazo [۴,۵-c]quinolin-۴-amine (IQA) in mice model. The current study allocated the thirty-two mice into four groups (n=۸) as follows: i) control group, mice where a white petroleum jelly base applied topically on the dorsal of mice once daily; ii) induction group, mice were received IQA cream (۶۲.۵ mg) of (۵%) on their back once daily; and iii) the treatment group, mice were treated with both (۶۲.۵ mg) of (۵%) IQA and (۵%) allopurinol gel topically; the betamethasone group, mice were treated with both (۶۲.۵ mg) of (۵%) IQA and betamethasone ointment topically. All groups were treated daily for seven days period. The allopurinol-treated group exerted non-significant differences compared with the induction group in both visional and histopathological changes. The present study revealed that the allopurinolgel (۵%) did not affect skin inflammation- induced by IQA in the laboratory mice.

Keywords:

Allopurinol , IQA , inflammation , dermatitis