Contribution of Hepatitis B Contribution to Anemia in Dialysis Patients with Chronic Renal Failure, Iraq

Chronic renal failure are caused by impaired kidney function; this organ is essential in the metabolism, filtration, and excretion of compounds. Human hepatitis B virus is common in dialysis patients with chronic renal failure, and chronic kidney disease (CKD) is also associated with anemia in dialysis patients. In this study, ۵۰ (۳۶ men and ۱۴ women) dialysis patients from Imamian Al-Khademian city, with ages between ۳۰ and ۷۷ years, and a healthy group (control group) with ages ranging between ۳۰ and ۶۲ years, were evaluated. Detection of hepatitis B virus by a molecular technique of real-time PCR and the concentration of erythropoietin hormone detected by the ELISA technique. The results showed that the prevalence of dialysis patients aged ۴۱–۵۰ and ۶۰–۵۱ was ۲۰% and ۱۸%, respectively. The detection of Hepatitis B from the serum of dialysis patients' samples showed that HBV was seen in ۱۵ (۳۰%) of the ۵۰ serum samples. The concentration of the erythropoietin hormone in dialysis patients’ samples was lower than in the healthy groups (a control group). Also, the concentration of erythropoietin hormone was significantly lower in dialysis patients compared with the control group (P>۰.۰۵). Hepatitis B can affect chronic renal failure and dialysis patients' immunity. Also, people with hepatitis B have a lower level of the erythropoietin hormone, which is a major cause of anemia in dialysis patients.

Keywords:

dialysis patients , kidney failure , hepatitis B virus , Erythropoietin hormone