Marrubium persicum İmproved the Biological Parameters Associated with Angiogenesis and İnflammation in Mice
Publish place: Archives of Razi Institute journal، Vol: 78، Issue: 1
Publish Year: 1402
نوع سند: مقاله ژورنالی
زبان: English
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JR_ARCHRAZI-78-1_029
تاریخ نمایه سازی: 6 دی 1402
Abstract:
The genus Marrubium, belonging to the family Lamiaceae, is highly praised in herbal medicine of different countries for having renowned healing properties. Herein, the anti-inflammatory and anti-angiogenesis potential of Marrubium persicum methanol extract was evaluated in a mouse air pouch model of inflammation. Aerial parts of M. persicum were solvent extracted using the Soxhlet apparatus. Subsequently, air injections were performed (for ۳ days) into the mice's backs to bring about an air pouch, while carrageenan was used to induce inflammation. The mice were divided into four groups, including; negative control (normal saline into the pouch), control (carrageenan), treatment and positive control (dexamethasone). The inflammatory markers were analyzed ۴۸h after injecting carrageenan, and a haemoglobin assay kit assessed the quantification of angiogenesis in granulation tissue. M. persicum methanol extract at doses of ۳.۵, ۵, ۷.۵ and ۱۰ mg/kg represented significant decreases in inflammatory parameters. Compared to the control group, the optimum dose (۳.۵ mg/kg) lessened the myeloperoxidase (MPO) and angiogenesis activity, as well as haemoglobin levels. In sum, the methanol extract of M. persicum exhibited anti-inflammatory effects against carrageenan-induced inflammation, which could be related to its antioxidant and inhibitory effects on neutrophils’ infiltration.
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Authors
K Fekri
Department of Paramedicine, Amol School of Paramedical Sciences, Mazandaran University of Medical Sciences, Sari, Iran
M. Sh Mortezaie
Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran
N Maleki-Dizaji
Department of Pharmacology and Toxicology, Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran
F Fathiazad
Department of Pharmacognosy, Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran
S Hamedeyazdan
Department of Pharmacognosy, Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran
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