Polycystic Ovary Syndrome Develops the Complications of Assisted Reproductive Technologies

Ovarian hyperstimulation syndrome (OHSS) is a serious complication that remains a threat to every patient experiencing stimulation of ovulation. Polycystic ovary syndrome (PCOS) appears to be the most important predisposing factor for OHSS. The severity of OHSS is associated with the degree of the follicular response to the ovulation inducing agents. The objective of this study was to investigate the relationship between PCOS with the risk of moderate-to-severe OHSS in intracytoplasmic sperm injection treatment patients. Sixty patients in the reproductive ages (۲۰-۳۸), including OHSS patients and age-matched normoresponders were included in this study. Patients who had larger follicle counts on the day of hCG injection were considered at risk for developing moderate-to-severe OHSS. In addition, oocyte quality was assessed about ۲۰-۳۰ min after oocyte pickup. The incidence of OHSS in PCOS patients increased significantly up to ۱۳.۹ times higher than in patients without PCOS (OR=۱۳.۹۰۰; P=۰.۰۰۷). Moreover, moderate-to-severe OHSS increased significantly (OR=۳.۸۶۰; P=۰.۰۴۳) in patients with primary infertility than those with secondary infertility. In addition, oocyte quality was not affected with the severity of OHSS. In conclusion, the risk of moderate-to-severe OHSS is correlated with PCOS and primary infertility without affecting oocyte quality.

Keywords:

Polycystic ovary syndrome , Ovarian Hyperstimulation Syndrome , Assisted reproductive technologies , Intracytoplasmic sperm injection