An Investigation of Vascular Endothelial Growth Factor (VEGFR-۱ and VEGFR-۲) in Burn Wound Healing

Burn damage is a complicated trauma that causes local and general tissue edema as a result of cell breakage and capillary leak syndrome. Angiogenesis plays a key part in the mechanisms that are initiated by tissue damage (e.g., burns) since it works directly and precisely on endothelial cells. The primary mediators of angiogenesis are vascular endothelial growth factor (VEGF) and its receptors (VEGFR-۱ and VEGFR-۲). This study aimed to figure out what functions VEGF and its receptors play in wound healing after burn, and the systemic release of VEGF in people following severe burn damage. This study included ۲۳ burnt adult serum and ۲۰ healthy controls. The enzyme-linked immunosorbent test was used to assess circulating VEGF serum levels and its receptors (VEGFR-۱ and VEGFR-۲). VEGF serum levels were considerably higher in this study, compared to VEGF levels in healthy controls. The levels of VEGFR-۱ and VEGFR-۲ have significantly risen; moreover, VEGF and its receptors have a significant impact on edema-related problems in severely burned individuals. Burn is a frequent disease that damages the skin and induces the production of mediators that cause neovasculature in the majority of patients. VEGF, which causes vasculogenesis and angiogenesis, is one of the most important factors in the skin.

Keywords:

Angiogenesis , Burns , VEGF , VEGF receptors (VEGFR-۱ and VEGFR-۲)