Correlation of Histamine Receptors and Adrenergic Receptor in Broilers Appetite
Publish place: Archives of Razi Institute journal، Vol: 77، Issue: 1
Publish Year: 1401
نوع سند: مقاله ژورنالی
زبان: English
View: 84
This Paper With 9 Page And PDF Format Ready To Download
- Certificate
- من نویسنده این مقاله هستم
استخراج به نرم افزارهای پژوهشی:
شناسه ملی سند علمی:
JR_ARCHRAZI-77-1_019
تاریخ نمایه سازی: 6 دی 1402
Abstract:
The current study was conducted to investigate the interaction between the central adrenergic and histaminergic systems and the broiler chick’s feed intake. In the first experiment, the intracerebroventricular (ICV) injection of solutions was conducted which included ۱۰ nmol of prazosin (an α۱-receptor antagonist), ۳۰۰ nmol of histamine, co-injection of prazosin and histamine. Experiments two to five were conducted similarly the same as the first experiment, in which chickens were ICV injected with ۱۳ nmol of yohimbine (an α۲-receptor antagonist), ۲۴ nmol of metoprolol (a β۱ adrenergic receptor antagonist), ۵ nmol of ICI ۱۱۸,۵۵۱ (a β۲ adrenergic receptor antagonist), and ۲۰ nmol of SR ۵۹۲۳۰R (a β۳ adrenergic receptor antagonist). The injected solutions in the sixth experiment included ۳۰۰ nmol of noradrenaline, ۲۵۰ nmol of α-FMH (an alpha fluoromethyl histidine), noradrenaline, and α-FMH. Seventh to ninth experiments were similar to the sixth experiment, except that the chickens were ICV injected with ۳۰۰ nmol of chlorpheniramine (a histamine H۱ receptors antagonist), ۸۲ nmol of famotidine (a histamine H۲ receptors antagonist), and ۳۰۰ nmol of thioperamide (a histamine H۳ receptors antagonist), rather than α-FMH. Afterward, the cumulative food intake was measured ۱۲۰ min after injection. Based on the obtained results, both histamine ICV injection and noradrenaline injection reduced food intake (P<۰.۰۵). Moreover, co-injection of histamine and ICI ۱۱۸,۵۵۱ (P<۰.۰۵), and co-injection of noradrenaline and Chlorpheniramine reduced food intake (P<۰.۰۵). In addition, noradrenaline and Thioperamide co-injection improved hypophagic effect of noradrenaline in neonatal chicken (P<۰.۰۵). These findings suggested the effect of interconnection between adrenergic and histaminergic systems, which may be mediated by H۱ and H۳ histaminergic and β۲ adrenergic receptors, on the regulation of food intake in the neonatal broiler chicken.
Keywords:
Authors
M Daneshvar
Department of Basic Sciences, Faculty of Veterinary Medicine, Science and Research Branch, Islamic Azad University, Tehran, Iran
M Zendehdel
Department of Basic Sciences, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran
B Vazir
Department of Basic Sciences, Faculty of Veterinary Medicine, Science and Research Branch, Islamic Azad University, Tehran, Iran
A Asghari
Department of Clinical Sciences and Technologies, Faculty of Veterinary Medicine, Science and Research Branch, Islamic Azad University, Tehran, Iran
مراجع و منابع این Paper:
لیست زیر مراجع و منابع استفاده شده در این Paper را نمایش می دهد. این مراجع به صورت کاملا ماشینی و بر اساس هوش مصنوعی استخراج شده اند و لذا ممکن است دارای اشکالاتی باشند که به مرور زمان دقت استخراج این محتوا افزایش می یابد. مراجعی که مقالات مربوط به آنها در سیویلیکا نمایه شده و پیدا شده اند، به خود Paper لینک شده اند :