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Polyomavirus-Associated Progressive Multifocal Leukoencephalopathy (PML) in HAART era

Publish place: Archives of Razi Institute journal، Vol: 71، Issue: 1
Publish Year: 1395
Type: Journal paper
Language: English
View: 102

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Link to this Paper:
https://civilica.com/doc/1868778

Document National Code:

JR_ARCHRAZI-71-1_001

Index date: 27 December 2023

Polyomavirus-Associated Progressive Multifocal Leukoencephalopathy (PML) in HAART era abstract

Polyomaviruses may cause human disease, particularly in immunocompromised hosts. JCV, one of the members of polyomaviridae family, is the causative agent of the neurological disease progressive multifocal leukoencephalopathy (PML), which occurs mostly in immunocompromised patients. Progressive Multifocal leukoencephalopathy (PML) is a progressive demyelinating disorder of the central nervous system (CNS) resulting from infection of oligodendrocytes by JC polyomavirus. Whereas after highly active antiretroviral therapy (HAART), the incidence of nearly all of all neurological complication have decreased, this article evaluates the incidence and prognosis of JC polyomavirus-associated PML including a unchangeable incidence of PML associated with JC polyomavirus compared with other opportunistic disease and paradoxical results of disease remission in HAART era.

Polyomavirus-Associated Progressive Multifocal Leukoencephalopathy (PML) in HAART era Keywords:

Polyomavirus , JCV , PML , HAART , Epidemiology

Polyomavirus-Associated Progressive Multifocal Leukoencephalopathy (PML) in HAART era authors

B Abedi Kiasari

Department of Human Viral Vaccine, Razi Vaccine and Serum Research Institute, Karaj, Iran

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