Evaluation of the Antioxidant Effects of Green Tea (Camellia sinensis) on Male Albino Mice poisoned with Thioacetamide

Background & Objectives: Effects of free radicals and reactive oxygen species (ROS) on biological systems have been one of the most important medical concerns. Production of free radicals and ROS is inherent to aerobic life. This study aimed to investigate the antioxidant effects of green tea (camellia sinensis) on male Albino mice poisoned with thioacetamide. Materials and Methods: In this study, thioacetamide was injected intraperitoneally at doses of ۱۰۰ and ۱۵۰ mg/kg. In addition, enzyme activity of catalase (CAT) and glutathione peroxidase (GPx), as well as the concentration of malondialdehyde (MDA) as the main source of antioxidants, were measured in all the study groups. Results: There was a significant increase in the activities of CAT and GPx, while a significant decrease was observed in the level of MDA in the mice receiving combined green tea and thioacetamide compared to the recipients of thioacetamide alone (P<۰.۰۵). Conclusion: According to the results of this study, the antioxidant properties of green tea are associated with the presence of a polyphenol called catechin in this plant.

Keywords:

Antioxidant , Catalase , Catechin , Free radicals , Glutathione peroxidise , Green tea , Malondialdehyde , Reactive oxygen species , Thioacetamide , چای سبز , رادیکال های آزاد , تیواستامید , کاتالاز , گلوتاتیون پراکسیداز , مالون دی آلدئید , کاتچین و آنت یاکسیدان.