Comparison of midazolam versus captopril in patients with uncomplicated hypertensive urgency in emergency ward: Double-blind randomized clinical trial

BACKGROUND: The urgency of uncomplicated blood pressure (BP) is known as a sudden rise in BP. The aim of this study was to evaluate the intravascular administration of midazolam as an emergency care to control BP against captopril in patients with uncomplicated hypertension (HTN).METHODS: The present study was a double-blind parallel randomized clinical trial (RCT) study that was performed on patients with urgent HTN referred to Imam Hossein Hospital in Shahroud, Iran, in ۲۰۱۸. Patients with BP higher than ۱۸۰/۱۱۰ mmHg and with healthy vital organs were selected randomly and allocated into three groups of ۴۳ participants. All patients’ BP in both arms, and after a period of ۱۰ minutes in the left arm, was checked and after administering the medication was checked again for ۴ times of ۱۵ minutes till ۱ hour complete.RESULTS: There were significant differences between systolic (P = ۰.۰۲۴), diastolic (P = ۰.۰۰۱), and mean BP (P = ۰.۰۰۹) in the midazolam group before and after treatment. The group of midazolam and captopril showed the greatest reduction of BP before, in the middle, and after carrying out the treatment methods. As such, systolic, diastolic, and mean BP showed ۲۳.۵% (P = ۰.۰۴۷), ۱۷.۴% (P = ۰.۰۲۱), and ۲۰.۵% (P = ۰.۰۳۱) reduction, respectively.CONCLUSION: Midazolam can be used as an effective and low-risk drug for lowering BP. Midazolam also has a faster effect on lowering BP.

Keywords:

Hypertension , Midazolam , Captopril , Emergency Medicine , Clinical Trial