Renoprotective effects of crocin against colistin-induced nephrotoxicity in a rat model
Publish place: Iranian Journal of Basic Medical Sciences، Vol: 27، Issue: 2
Publish Year: 1403
نوع سند: مقاله ژورنالی
زبان: English
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JR_IJBMS-27-2_003
تاریخ نمایه سازی: 16 دی 1402
Abstract:
Objective(s): Colistin is used to treat multidrug-resistant gram-negative bacterial infections. It increases the membrane permeability of kidney cells, leading to kidney toxicity. Crocin, a carotenoid found in saffron, has anti-oxidant and nephroprotective properties. The present study aimed to explore the potential renoprotective effects of crocin against colistin-induced nephrotoxicity.Materials and Methods: Six groups of male Wistar rats were utilized: ۱- Control (۰.۵ ml of normal saline, ۱۰ days, IP); ۲- Crocin (۴۰ mg/kg, ۱۰ days, IP); ۳-Colistin (۲۳ mg/kg, ۷ days, IP); ۴-۶ Colistin (۲۳ mg/kg, ۷ days, IP)+ crocin (۱۰, ۲۰, ۴۰ mg/kg, ۱۰ days, IP). On day ۱۱, rats were sacrificed and their blood and kidney samples were collected to measure creatinine, blood urea nitrogen (BUN), glutathione (GSH) levels, malondialdehyde (MDA), and histopathological alterations.Results: Colistin caused a significant increase in BUN, creatinine, and MDA, and a decrease in GSH compared to the control group. It also led to congested blood vessels, glomerular shrinkage, and medullary tubular degeneration. Co-administration of crocin with colistin resulted in a significant decrease in BUN and creatinine, increased GSH levels, and ameliorated the histopathological alterations compared to the colistin group. No significant difference was found between the control group and the crocin (۴۰ mg/kg) group.Conclusion: It might be suggested that colistin can induce kidney damage by inducing oxidative stress. However, crocin shows protective effects against colistin-induced renal injury by acting as an anti-oxidant. Hence, crocin can be used as a supplement to reduce tissue and biochemical damage caused by colistin injection.
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Authors
Reza Rajabalizadeh
Department of Pharmacodynamics and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran
Mahboobeh Ghasemzadeh Rahbardar
Pharmaceutical Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran
Bibi Marjan Razavi
Pharmaceutical Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran
Hossein Hosseinzadeh
Department of Pharmacodynamics and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran
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