Gamma-Glutamyl Transferase and the Risk of Type ۲ Diabetes Mellitus: A Review

Publish Year: 1402
نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:

JR_IJDO-15-4_006

تاریخ نمایه سازی: 18 دی 1402

Abstract:

The relationship between gamma-glutamyl transferase (GGT) levels and risk factors for type ۲ diabetes mellitus (T۲DM) and the risk of incident T۲DM was assessed using a narrative review of available evidence. Higher circulating levels of GGT are associated with an increased risk of type ۲ diabetes mellitus, suggesting GGT as a risk predictor of T۲DM. The incidence of type ۲ diabetes and its association with GGT elevation could be explained by oxidative stress in cells followed by subclinical inflammation and fatty liver, leading to impaired insulin secretion and insulin resistance. A strong correlation is evident between BMI and GGT, in which hepatic steatosis and insulin resistance are proposed to be the intermediate connecting characteristics.

Keywords:

Gamma-glutamyl transferase , Type ۲ diabetes mellitus , Body mass index

Authors

Sachini M Thennakoon

Department of Biomedical Sciences, Faculty of Science, NSBM Green University, Mahenwatta, Pitipana, Homagama (۱۰۲۰۶), Sri Lanka

Niroshima D Withanage

Department of Medical Laboratory Sciences, Faculty of Allied Health Sciences, University of Sri Jayewardenepura, Nugegoda, Sri Lanka.

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