Fabrication and numerical optimization of microfluidic-based spiral micromixer

In this paper, recommended spiral passive micromixer was designed and simulated. spiral design has the potential to create and strengthen the centrifugal force and the secondary flow. A series of simulations were carried out to evaluate the effects of channel width, channel depth, the gap between loops, and flowrate on the micromixer performance. These features impact the contact area of the two fluids and ultimately lead to an increment in the quality of the mixture. In this study, for the flow rate of ۲۵ μl/min and molecular diffusion coefficient of ۱×۱۰-۱۰ m۲/s, mixing efficiency of more than ۹۰% is achieved after ۳۰ (approximately one-third of the total channel length). Finally, the optimized design fabricated using proposed ۳D printing method.

Keywords:

Microfluidics , Micromixer , Drug Delivery System , Polymeric Micelles , Numerical optimization