Effect of Foretinib on Matrix Metalloproteinase-2 (MMP2) Expression in Glioblastoma
Publish place: Research in Molecular Medicine، Vol: 6، Issue: 4
Publish Year: 1397
Type: Journal paper
Language: English
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Document National Code:
JR_REMJ-6-4_002
Index date: 12 January 2024
Effect of Foretinib on Matrix Metalloproteinase-2 (MMP2) Expression in Glioblastoma abstract
Background: The most malignant form of infiltrating astrocytoma, glioblastoma multiforme (GBM), is one of the most aggressive human cancers. Foretinib diminished GBM cell invasion by downregulating the expression of matrix metalloproteinase 2 (MMP2). The study aimed to examine the anti-tumor activity of foretinib and to test its effect on MMP2 expression in T98 cells.
Materials and methods: T98 cells were used as an experimental model of glioblastoma. The effect of foretinib on the expression of MMP2 was evaluated using quantitative real-time polymerase chain reaction. Thereafter, the effect of foretinib on the enzyme levels of MMP was examined by zymography. Statistical analyses were performed with GraphPad Prism software.
Results: A reduction in the expression of MMP2 was observed with an increase in the concentration of foretinib.
Conclusion: Foretinib treatment leads to downregulation of MMP-2 and has a positive effect on T98 cells. We believe that foretinib can be subjected to further clinical investigation to develop a treatment for GBM.
Effect of Foretinib on Matrix Metalloproteinase-2 (MMP2) Expression in Glioblastoma Keywords:
Effect of Foretinib on Matrix Metalloproteinase-2 (MMP2) Expression in Glioblastoma authors
Maryam Fotoohi
Medical Biotechnology Research Center, Ashkezar Branch, Islamic Azad University, Ashkezar, Yazd, Iran.
Nasrin Hadi
Medical Biotechnology Research Center, Ashkezar Branch, Islamic Azad University, Ashkezar, Yazd, Iran.
Faezeh Namazi
Medical Biotechnology Research Center, Ashkezar Branch, Islamic Azad University, Ashkezar, Yazd, Iran.
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