Association of Methylenetetrahydrofolate Reductase (MTHFR) Gene C۶۷۷T and A۱۲۹۸C Polymorphisms with Myocardial Infarction From North of Fars Province

Background: The association between Methylene tetrahydrofolate reductase polymorphism and Coronary Artery diseases risk has been both confirmed and refuted in a number of published studies. The aim of this study was to investigate whether genetic polymorphisms of MTHFR (C۶۷۷T, A۱۲۹۸C) contributed to the development of myocardial infarction (MI). Materials and Methods: The present case-control study consisted of ۵۴ patients with a history of MI and ۵۴ gender-matched normal controls. The SNPs genotypes were determined using polymerase chain reaction followed by restriction fragment length polymorphism method. Results: No significant association of the MTHFR A۱۲۹۸C with the risk of MI was observed. However, the allele frequencies of C۶۷۷T SNP differed significantly among patients and controls (۰.۸۳ vs. ۰.۳۰). A strong positive relationship between the TT genotype and the risk of MI supported with a significant p-value < ۰.۰۰۱ (OR= ۱۱.۸۷, ۹۵% CI: ۴.۷- ۲۹.۹, p < ۰.۰۰۱). Conclusions: The results of the present study show the importance of C۶۷۷T SNP as a potential biomarker for screening susceptible cases to MI.

Keywords:

Methylenetetrahydrofolate Reductase , Myocardial infarction , polymorphism