Stability analysis of the transmission dynamics of an HBV model
Publish Year: 1395
نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:
JR_IJIM-8-2_003
تاریخ نمایه سازی: 27 دی 1402
Abstract:
Hepatitis B virus (HBV) infection is a major public health problem in the world today. A mathematical model is formulated to describe the spread of hepatitis B, which can be controlled by vaccination as well as treatment. We study the dynamical behavior of the system with fixed control for both vaccination and treatment. The results shows that the dynamics of the model is completely determined by the basic reproductive number R_۰. if R_۰<۱, the disease-free equilibrium is globally asymptotically stable by using approach that given by Kamgang and Sallet. Then the authors prove that if R_۰>۱, the disease-free equilibrium is unstable and the disease is uniformly persistent. Furthermore, If R_۰>۱, the unique endemic equilibrium is globally asymptotically stable by using a generalization of the Poincar e-Bendixson criterion.
Keywords:
Hepatitis B virus (HBV) , Basic reproduction number (R_۰) , Gompound matrices , Global stability.
Authors
R. Akbari
Department of Mathematical Sciences, Payame Noor University ,P.O.Box ۱۹۳۹۵-۳۶۹۷ , Tehran ,Iran.
A. Vahidian Kamyad
Department of Mathematics Sciences , University of Ferdowsi, Mashhad, Iran.
A. A. Heydari
Research Center for Infection Control and Hand Hygiene, Mashhad University Of Medical Sciences, Mashhad, Iran.
A. Heydari
Department of Mathematical Sciences, Payame Noor University, P. O. Box ۱۹۳۹۵-۳۶۹۷, Tehran, Iran.