Nonenzymatic Electrochemical Detection of Glucose Using Screen-Printed Electrode Modified with Pd‒Au Nanoparticles Encapsulated on Dendrimer Grafted Multi-Wall Carbon Nanotubes

A novel nonenzymatic glucose sensor based on palladium‒gold nanoparticles encapsulated on polypropylene amine dendrimer–grafted multi-wall carbon nanotubes (PdAu/PPI‒MWCNTs) has been successfully fabricated and applied to glucose detection. PdAu/PPI‒MWCNTs was prepared in a three‒step process. First, polypropylene amine (PPI) dendrimers were grown on the surface of functionalized multi-wall carbon nanotubes (MWCNTs‒NH2) by a divergent method; second, metal ions were trapped within the dendrimers; and third, the ions were chemically reduced. Therefore, the well-distributed nanoparticles with an average size range of 1.6-3.2 nm were obtained on the surface of PPI‒MWCNTs. The prepared PdAu/PPI‒MWCNTs nanocomposite was immobilized on screen-printed carbon electrode and its electrocatalytic activity for glucose oxidation reaction was studied. Under the optimized conditions, the glucose oxidation current was linear to its concentration within the range of 0.03 ‒ 3.0 mM, and the detection limit was found to be 0.01 mM (S/N = 3). Finally, the prepared sensor has been successfully applied to determine the glucose content in human blood serum samples.

Nonenzymatic Electrochemical Detection of Glucose Using Screen-Printed Electrode Modified with Pd‒Au Nanoparticles Encapsulated on Dendrimer Grafted Multi-Wall Carbon Nanotubes Keywords:

Palladium‒gold nanoparticles , Dendrimer-encapsulated NPs , Glucose , Electrochemical sensor , Carbon nanotubes , screen-printed electrode