Evaluation of the Effects of Injection Velocity and Different Gel Concentrations on Nanoparticles in Hyperthermia Therapy

Background and objective: In magnetic fluid hyperthermia therapy, controlling temperature elevation and optimizing heat generation is an immense challenge in practice. The resultant heating configuration by magnetic fluid in the tumor is closely related to the dispersion of particles, frequency and intensity of magnetic field, and biological tissue properties.Methods: In this study, to solve heat transfer equation, we used COMSOL Multiphysics and to verify the model, an experimental setup has been used. To show the accuracy of the model, simulations have been compared with experimental results. In the second part, by using experimental results of nanoparticles distribution inside Agarose gel according to various gel concentration, ۰.۵%, ۱%, ۲%, and ۴%, as well as the injection velocity, ۴ µL/min, ۱۰ µL/min, ۲۰ µL/min, and ۴۰ µL/min, for ۰.۳ cc magnetite fluid, power dissipation inside gel has been calculated and used for temperature prediction inside of the gel.Results: The Outcomes demonstrated that by increasing the flow rate injection at determined concentrations, mean temperature drops. In addition, ۲% concentration has a higher mean temperature than semi spherical nanoparticles distribution.Conclusion: The results may have implications for treatment of the tumor and any kind of cancer diseases.

Keywords:

Hyperthermia , Bio-heat transfer equation , Magnetic fluid , Nanoparticles distribution , Power dissipation