Diagnosis and Treatment of Small Bowel Cancers Using Radioactive Gold Nanoparticles and Wireless Fluorescence Capsule Endoscopy

Background: Therapeutic and diagnosis properties of radioactive gold nanoparticle (۱۹۸-AuNPs) cause them to be suitable for detection and treatment of tumors.Objective: Electrical and optical properties of PEG-۱۹۸AuNPs were examined in this paper. Polyethylene Glycol (PEG)-۱۹۸ AuNPs can be used for treatment and diagnosis of small intestine tumors.Methods: Wireless fluorescence capsule endoscopy will be able to detect emission lights of triggered Au by external light. First, the output electrical field was calculated by DDSCAT software. Secondly, tumor and distribution of PEG-۱۹۸ gold nanoparticles were modeled using Monte Carlo simulation and finally dose delivered throughout a solid tumor when the PEG-۱۹۸ gold nanoparticles linked to each cell was calculated.Results: Polyethylene Glycol functionalized gold nanoparticles (AuNPs) possess optimized sizes (۳۰ nm core diameter and ۷۰ nm hydrodynamic diameters) to target individual tumor cells. Surface distribution to receive doses of up to ۵۰Gy was simulated.  Activities and absorbed doses by the tumors with ۰.۲۵cm and ۰.۵cm radius were ۱۸۷.۹mCi and ۳۰۰mCi and ۷۲ and ۱۱۸ Gy,respectively. Conclusion: Therapeutic and diagnosis properties of ۱۹۸-AuNPs show that it can be used for treatment and detection of small bowel tumors in early stage of growing.Â

Keywords:

Radioactive gold nanoparticle , Wireless fluorescence capsule endoscopy , Small intestine , Polyethylene Glycol , Dose , Activity