Effect of Hydroalcoholic Extract of Solanum Melongena on Mast Cell Numbers and Degranulation in Diabetic Rat Wound Healing
Publish place: 10th International Congress of Wound and Tissue Repair
Publish Year: 1402
نوع سند: مقاله کنفرانسی
زبان: English
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شناسه ملی سند علمی:
WTRMED10_041
تاریخ نمایه سازی: 1 بهمن 1402
Abstract:
Objective: Many studies have revealed the prominent effects of mast cells in wound healing. In the present study, we assessed the probable therapeutic features of Solanum melongena hydroalcoholic extract on mast cell degranulation in experimental diabetic rats.Method: Skin wounds were generated and treatments were applied with Solanum melongena hydroalcoholic extract intraperitoneally in the sham, control and experimental groups, respectively. Animals were euthanised on days ۳,۵,۷ and۱۵. ۱۶.۸۰۰ microscopic images used to count the mast cells and degranulation level (stereology test, Image J software).Results: Time-lapse photography revealed that Solanum melongena significantly (p<۰.۰۵) increased the total number of mast cells in all experimental groups on days ۵ and ۷. The count of grade III (degranulated) mast cells was reduced significantly (p<۰.۰۵) on days ۵ and ۷ in experimental groups.Conclusion: The rate of wound healing was accelerated considerably following Solanum melongena hydroalcoholic extract administration.
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Authors
Amene Nikgoftar Fathi
MSc of anatomical sciences, Department of Anatomical Sciences, Medical School, ArakUniversity of Medical Sciences, Arak, Iran