Valine Consumption And Endurance Exercise Modified The Inflammation In Rat Model Of Anxiety/Depression.

Background: Depression and anxiety are disabling conditions with side effects on cognition, quality of life, memory, and mood. Anxiety is a dysregulated mood condition that could disturb cognition. The present study aimed to evaluate the effect of dietary interventions and endurance training in managing anxiety and depressive symptoms.Methods: In this study, ۳۰ rats were divided into five groups: Normal group, anxiety/ depression group, rat model of anxiety/depression who consumed valine ۳.۰ μmol/۵۰۰ μl intraperitoneal injection once/day for eight weeks, rat model of anxiety/depression who conducted endurance training (۳۲ m/min for ۴۵ minutes/session, six days a week for eight weeks), and rat model of anxiety/depression who conducted endurance training (۷۵% VO۲max) and consumed valine (۳.۰ μmol/۵۰۰ μl). The level of anxiety/depression was evaluated by behavior open field tests and relative expression assay of the genes related to the inflammation.Results: Findings indicated that the expression level of the NF-κB and TNFα significantly increased in the anxiety/depression group. Moreover, the endurance training and consumed valine  improved the NF-κB and TNFα expression in the brain of the rat  model of anxiety/depression. In addition, endurance training and consuming valine  decreased the anxiety/depression level.Conclusion: Endurance training and consuming valine  reduced the brain's inflammation level and improved the anxiety/depression level.

Keywords:

anxiety , Depression Valine , Endurance training , Brain