[۹۹mTc]Tc-TRODAT-۱ scan diagnostic accuracy for differentiation of dementia of Lewy body from Alzheimer’s disease

Publish Year: 1403
نوع سند: مقاله ژورنالی
زبان: English
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JR_IRJNM-32-1_007

تاریخ نمایه سازی: 8 بهمن 1402

Abstract:

Introduction: Dopamine transporter (DAT) receptors are reduced in the striatum in dementia of Lewy body (DLB) but normal in Alzheimer’s disease (AD). We assessed the diagnostic accuracy of TRODAT-۱ imaging to differentiate patients with DLB from AD.Methods: Patients with DLB or AD underwent SPECT TRODAT imaging by [۹۹mTc]Tc-TRODAT-۱. Visual interpretation and quantification analyses were done. The activity of the right and left caudate nucleus (CN), putamen (P), striatum (S) as a whole, background (BG), and occipital area (OC) were calculated in addition to the ratio of right and left CN/OC, P/OC, and S/BG. Absolute right and left value difference of the striatum (∆S), putamen (∆P), and caudate (∆CN) to OC or BG were also calculated. The diagnostic accuracy of the visual and quantitative method were compared between patients with AD and LBD. The area under the ROC curve (AUC) was analyzed.Results: Twenty-five patients (۱۵ DLB and ۱۰ AD) were included. Scans were visually interpreted as DLB, AD, and non-diagnostic in ۱۱, ۱۳, and one patients, respectively. Sensitivity, specificity, and accuracy of the scan were ۵۷.۱% (۲۸.۹-۸۲.۳), ۷۰% (۳۴.۸-۹۳.۳), and ۶۲.۵% (۴۰.۶-۸۱.۲), respectively. CN/OC, P/OC, and S/BG in the left, right, and bilaterally were statistically same between two groups. The AUC of ∆CN/OC was ۷۰.۷%.  The optimal cut-off value for ∆CN/BG to diagnose DLB was ۶.۶% with a sensitivity, specificity, and accuracy, of ۸۶.۷%, ۵۰%, and ۷۲.۰%, respectively.Conclusion: The [۹۹mTc]Tc-TRODAT-۱ imaging has limited diagnostic accuracy for discrimination of DLB and AD patients.

Authors

Farzaneh Baseri

Research Center for Nuclear Medicine, Tehran University of Medical Sciences, Tehran, Iran

Vajiheh Aghamollaii

Department of Neurology, Roozbeh Hospital, Tehran University of Medical Sciences, Tehran, Iran

Yalda Salehi

Department of Nuclear Medicine, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran

Saeed Farzanefar

Department of Nuclear Medicine, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran

Ali Hosseini

Department of Nuclear Medicine, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran

Abbas Tafakhori

Department of Neurology, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran

Mehrshad Abbasi

Department of Nuclear Medicine, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran

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