Comparing the diagnostic efficacy of [۹۹mTc]Tc-HYNIC-PSMA-۱۱ SPECT/CT scanning after ۷۵ minutes and ۴ hours of radiotracer injection in men with prostate cancer

Publish Year: 1403
نوع سند: مقاله ژورنالی
زبان: English
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JR_IRJNM-32-1_003

تاریخ نمایه سازی: 8 بهمن 1402

Abstract:

Introduction: Prostate-Specific Membrane Antigen (PSMA) is overexpressed in primary and metastatic prostate carcinoma (PCa) and could be targeted by a [۹۹mTc]Tc-HYNIC-PSMA-۱۱ scan for detection of metastases. Despite extensive studies, data on the most appropriate interval between radiopharmaceutical injection and image acquisition is scarce. We compared the metastasis detection rates of the [۹۹mTc]Tc-HYNIC-PSMA-۱۱ scan between ۷۵-minute and ۴-hour intervals of radiopharmaceutical injection.Methods: From May ۲۰۲۱ to May ۲۰۲۲, we studied ۳۰ consenting men with pathologically confirmed PCa who were referred to our department requesting  a PSMA scan for primary staging, biochemical recurrence, pre-۱۷۷Lu-PSMA therapy, or surveillance. ۷۵-minute and ۴-hour [۹۹mTc]Tc-HYNIC-PSMA-۱۱ SPECT/CT scan performed following injection of the radiopharmaceutical. The corresponding  metastasis detection rates were evaluated in ۷۵-minute and ۴-hour intervals.Results: The mean age of patients was ۶۸.۴۳±۹.۶۱ years, with a median PSA of ۴.۱۹ ng/ml and a median Gleason Score of ۸. Nine cases had negative [۹۹mTc]Tc-HYNIC-PSMA-۱۱ scans, while ۲۱ had positive scans (۸ cases with bone, ۲ with lung, ۴ with lymph node, and ۷ with multiple organ metastases). All metastases were detected in both checkpoints, except for one patient, where ۷۵-minute images detected three pelvic metastatic lymph nodes, while four were seen in the ۴-hour scan. This small missed right external iliac lymph node did not change the patient’s management.Conclusion: We found no significant difference in the detection rate of metastatic lesions in ۷۵-minute and ۴-hour time intervals. These findings could help to decrease  waiting time and  by more efficient scheduling improves patient’s satisfaction at nuclear medicine departments.

Authors

Azadeh Sahebkari

Nuclear Medicine Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

Salman Soltani

Kidney Transplantation Complications Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

Hamidreza Ghorbani

Kidney Transplantation Complications Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

Kamran Aryana

Nuclear Medicine Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

Mona Kabiri

Pharmaceutical Nanotechnology Research Center, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran

Kayvan Sadri

Nuclear Medicine Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

Mahdi Mottaghi

Kidney Transplantation Complications Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

Atena Aghaee

Nuclear Medicine Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

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