Attenuation of acrylamide-induced neurotoxicity by supplementation of sitagliptin in Wistar rats

Publish Year: 1403
نوع سند: مقاله ژورنالی
زبان: English
View: 40

This Paper With 8 Page And PDF Format Ready To Download

  • Certificate
  • من نویسنده این مقاله هستم

استخراج به نرم افزارهای پژوهشی:

لینک ثابت به این Paper:

شناسه ملی سند علمی:

JR_IJBMS-27-3_007

تاریخ نمایه سازی: 8 بهمن 1402

Abstract:

Objective(s): Acrylamide (ACR) induces neurotoxicity in humans and animals through different mechanisms. Sitagliptin is a type-۲ diabetes medication with neuroprotective properties. The effects of sitagliptin against neurotoxicity stimulated by ACR were examined.Materials and Methods: Male Wistar rats were classified as follows: ۱. Control (normal saline, ۱۱ days, IP), ۲. ACR (۵۰ mg/kg, ۱۱ days, IP), ۳. ACR (۱۱ days, days ۱۱-۲۰ normal saline), ۴-۷. ACR+sitagliptin (۵, ۱۰, ۲۰, and ۴۰ mg/kg, ۱۱ days, IP), ۸. ACR+sitagliptin (۱۰ mg/kg, days ۶-۱۱), ۹. ACR+sitagliptin (۱۰ mg/kg, days ۶-۲۰), ۱۰. Sitagliptin (۴۰ mg/kg, ۱۱ days), ۱۱. ACR+vitamin E (۲۰۰ mg/kg, IP). Finally, the gait score was evaluated. Reduced glutathione (GSH) and malondialdehyde (MDA) levels were measured in cortex tissue.  Also, IL-۱β, TNF-α, and caspase-۳ levels were assessed in the cortex by western blotting. Results: ACR caused movement disorders, triggered oxidative stress, and raised TNF-α, IL-۱β, and caspase-۳ cleaved levels. Supplementation of sitagliptin (۱۰ mg/kg) along with ACR, in ۳ protocols, reduced gait disorders compared to the ACR group. Receiving sitagliptin in all doses plus ACR and injection of sitagliptin (۱۰ mg/kg) from days ۶ to۱۱ reduced the MDA level of cortex tissue. Sitagliptin (all doses) plus ACR increased the GSH level of the cortex tissue. Sitagliptin (۱۰ mg/kg) with ACR dropped the amounts of TNF-α and caspase-۳ cleaved proteins in cortex tissue but did not affect the IL-۱β level.Conclusion: Sitagliptin disclosed preventive and therapeutic effects on ACR neurotoxicity. Sitagliptin possesses antioxidant, anti-inflammatory, and anti-apoptotic properties and inhibits CR neurotoxicity in rats.

Authors

Mahboobeh Navabi

Department of Pharmacodynamics and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran

Mahboobeh Ghasemzadeh Rahbardar

Pharmaceutical Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran

Soghra Mehri

Department of Pharmacodynamics and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran

Hossein Hosseinzadeh

Department of Pharmacodynamics and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran

مراجع و منابع این Paper:

لیست زیر مراجع و منابع استفاده شده در این Paper را نمایش می دهد. این مراجع به صورت کاملا ماشینی و بر اساس هوش مصنوعی استخراج شده اند و لذا ممکن است دارای اشکالاتی باشند که به مرور زمان دقت استخراج این محتوا افزایش می یابد. مراجعی که مقالات مربوط به آنها در سیویلیکا نمایه شده و پیدا شده اند، به خود Paper لینک شده اند :
  • Koszucka A, Nowak A, Nowak I, Motyl I. Acrylamide in ...
  • Ghasemzadeh Rahbardar M, Hemadeh B, Razavi BM, Eisvand F, Hosseinzadeh ...
  • Kianfar M, Nezami A, Mehri S, Hosseinzadeh H, Hayes AW, ...
  • Wei X, Yan F, Meng E, Zhang C, Li G, ...
  • Yazadanpanah Z, Ghasemzadeh Rahbardar M, Razavi BM, Hosseinzadeh H. Investigating ...
  • Foroutanfar A, Mehri S, Kamyar M, Tandisehpanah Z, Hosseinzadeh H. ...
  • Karimi M, Ghasemzadeh Rahbardar M, Razavi BM, Hosseinzadeh H. Amifostine ...
  • Hung C-C, Cheng Y-W, Chen W-L, Fang W-H. Negative association ...
  • Rameshrad M, Razavi BM, Ferns GA, Hosseinzadeh H. Pharmacology of ...
  • Rameshrad M, Razavi BM, Lalau J-D, De Broe ME, Hosseinzadeh ...
  • Pennisi M, Malaguarnera G, Puglisi V, Vinciguerra L, Vacante M, ...
  • Sengul E, Gelen V, Yildirim S, Tekin S, Dag Y. ...
  • Goudarzi M, Mombeini MA, Fatemi I, Aminzadeh A, Kalantari H, ...
  • Kurebayashi H, Ohno Y. Metabolism of acrylamide to glycidamide and ...
  • Scott LJ. Sitagliptin: a review in type ۲ diabetes. Drugs ...
  • Wiciński M, Wódkiewicz E, Słupski M, Walczak M, Socha M, ...
  • Li Y, Zheng M, Sah SK, Mishra A, Singh Y. ...
  • Jo CH, Kim S, Park J-S, Kim G-H. Anti-inflammatory action ...
  • El-Sahar AE, Safar MM, Zaki HF, Attia AS, Ain-Shoka AA. ...
  • Abuelezz SA, Hendawy N, Abdel Gawad S. Alleviation of renal ...
  • Ghasemzadeh Rahbardar M, Cheraghi Farmed H, Hosseinzadeh H, Mehri S. ...
  • Mehri S, Abnous K, Khooei A, Mousavi SH, Shariaty VM, ...
  • Mondragon A, Davidsson D, Kyriakoudi S, Bertling A, Gomes-Faria R, ...
  • Mehri S, Shahi M, Razavi BM, Hassani FV, Hosseinzadeh H. ...
  • Tabeshpour J, Mehri S, Abnous K, Hosseinzadeh H. Neuroprotective effects ...
  • Moron MS, Depierre JW, Mannervik B. Levels of glutathione, glutathione ...
  • Rahbardar MG, Eisvand F, Rameshrad M, Razavi BM, Hosseinzadeh H. ...
  • Shahroudi MJ, Mehri S, Hosseinzadeh H. Anti-aging effect of Nigella ...
  • Ghobakhlou F, Eisvand F, Razavi BM, Ghasemzadeh Rahbardar M, Hosseinzadeh ...
  • Oskouei Z, Mehri S, Kalalinia F, Hosseinzadeh H. Evaluation of ...
  • Ghasemzadeh Rahbardar M, Razavi BM, Hosseinzadeh H. Investigating the ameliorative ...
  • Ghasemzadeh Rahbardar M, Razavi BM, Naraki K, Hosseinzadeh H. Therapeutic ...
  • LoPachin RM, Gavin T. Molecular mechanism of acrylamide neurotoxicity: lessons ...
  • Mehri S, Karami HV, Hassani FV, Hosseinzadeh H. Chrysin reduced ...
  • Mehri S, Dadesh Q, Tabeshpour J, Vahdati Hassani F, Karimi ...
  • Mehri S, Meshki MA, Hosseinzadeh H. Linalool as a neuroprotective ...
  • Wang CH, Zhu N. Protective role of sitagliptin against oxidative ...
  • Liu Y, Zhang X, Yan D, Wang Y, Wang N, ...
  • Acaroz U, Ince S, Arslan-Acaroz D, Gurler Z, Kucukkurt I, ...
  • Guo J, Cao X, Hu X, Li S, Wang J. ...
  • Tsai T-H, Sun C-K, Su C-H, Sung P-H, Chua S, ...
  • Kim B, Yun J, Park B. Methamphetamine-induced neuronal damage: neurotoxicity ...
  • Chipuk JE, Moldoveanu T, Llambi F, Parsons MJ, Green DR. ...
  • Gavathiotis E, Reyna DE, Davis ML, Bird GH, Walensky LD. ...
  • Kekre N, Griffin C, McNulty J, Pandey S. Pancratistatin causes ...
  • Salvesen GS, Dixit VM. Caspase activation: the induced-proximity model. Proc ...
  • He Y, Tan D, Bai B, Wu Z, Ji S. ...
  • نمایش کامل مراجع