Evaluation of Coagulation Parameters in Mice Treated with Terminalia bellirica (Gaertn.) Roxb. Extract

Publish Year: 1403
نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:

JR_JJMPB-13-1_012

تاریخ نمایه سازی: 8 بهمن 1402

Abstract:

Coagulation disorders and bleeding are the main problems among people with hemophilia. Although its common treatment is replacement therapy, the effects of herbs on bleeding treatment has been proven. In this study, the coagulation effect of the Terminalia bellirica (Gaertn.) Roxb. hydro-alcoholic extract was evaluated. ۳۲ mice were randomly divided into four groups (n = ۸) and received single doses of ۲۰۰۰, ۱۵۰۰, ۱۰۰۰ or ۵۰۰ mg/kg/day. Blood samples were taken from the animals ۱۴-۱۶ days after treatment, and coagulation indices were examined including PT, aPTT, BT, CT, and platelets. The hydro-alcoholic extract of T. bellirica significantly reduces bleeding time in the BT test (۱۰-fold) and increases platelet numbers (four-fold), showing the effect of this extract on initial homeostasis. A significant reduction of coagulation time in the CT test (five-fold) also indicates the effect of this plant extract on platelet aggregation. Moreover, the results showed the effectiveness of T. bellirica hydroalcoholic extract in the extrinsic coagulation pathway because all concentrations reduced the coagulation time in the PT test. Furthermore, given the ineffectiveness of the T. bellirica extract on the aPTT test, this extract probably had no effect on intrinsic coagulation factors. Considering the results, T. bellirica extract seems to have a coagulation effect on primary homeostasis and extrinsic pathway of secondary homeostasis.

Authors

Ihktiyar Mohammad Safi

Department of Biology, Hakim Sabzevari University, Sabzevar, Iran

Jafar Vatandoost

۱Department of Biology, Hakim Sabzevari University, Sabzevar, Iran

Fatemeh Sadeghifar

Department of Biology, Hakim Sabzevari University, Sabzevar, Iran

Toktam Hajjar

Department of Biology, Hakim Sabzevari University, Sabzevar, Iran

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