Comparison of the Anti-Fungal Effect of Electro-Spinning Drug-Loaded Nano-Fibers and Pad Dry Drug-Loaded Fabrics

In this research, the anti-fungal effect of fluconazoleloaded polyvinyl alcohol (PVA) nano-fibers was compared with that of drug-loaded fabric (DLF) to be used in medical textiles and fibrous pads as a local drug delivery system. The drug-loaded nano-fibers (DLNs) were coated on the fabric surface using the electro-spinning process. The DLF was then prepared by means of the pad-dry method. The characterization of the samples was carried out by SEM, FTIR, and XRD tests. UV-V is spectrophotometry was also used to measure the drug release rate. The anti-fungal effect was studied by the disk diffusion method. The drug release test showed about ۷۵% fluconazole release in ۹۰ min and the disc diffusion test indicated that the DLF has more effect than the DLN due to the fast drug release.

Keywords:

Nano-fibers , candida albicans , Vulvovaginal candidiasis , Fluconazole , Drug delivery system