The Effect of Continuous and Interval aerobic Trainings on Body Mass Index and Serum Levels of ICAM-۱ and VCAM-۱ in Men with Heart Failure

Introduction: Adhesive molecules of cellular markers have been applied to identify the process of formation of atherosclerotic plaque of vascular endothelial wall. The present research aimed to evaluate the effect of continuous and interval aerobic trainings on body mass index and serum levels of ICAM-۱ and VCAM-۱ in men with heart failure. Methods: In the present research, ۴۲ middle-aged men with heart failure were purposefully and randomly divided to three equal groups (each ۱۴ participants) including continuous, periodic, and control aerobic exercises. Continuous exercise (with the intensity of ۴۵-۷۰% maximum heart rate) and periodic exercises (with the intensity of ۴۵-۸۰% of MHR) were done for ۳ days a week, with a total term of ۸ weeks. Before and after the implementation of the exercise plan, blood samples were taken from three groups. Data were analyzed by one-way ANOVA (P≤۰.۰۵). Results: Comparison of mean of intra-group indicated a significant decrease in the level of cellular adhesion molecule-۱ and vascular adhesion molecules-۱ and body mass index in the exercise groups (P≤۰.۰۵). In Intragroup comparison, the two groups of exercise, VCAM-۱(P=۰.۰۰۰۱) and body mass index (P=۰.۰۰۲) were significantly decreased, but no significant change was observed in ICAM-۱(P=۰.۱۰۷). Decrease in VCAM-۱ levels and BMI between the two exercise groups were more significant than the control group, but there was no significant difference between the two groups of periodic and aerobic. Conclusion: With decreasing BMI and VCAM-۱ levels, aerobic exercises may have a significant role in the prevention and control of cardiovascular disease in patients with heart failure.

Keywords:

ICAM-۱ , VCAM-۱ , BMI , Aerobic Training , Heart Failure