Preliminary assessment of the antiproliferative potential of Ananas comosus (pineapple) fruit juice

Introduction: Cancer is a complex genetic ailment and a significant public health disease. Reports have shown that about ۳۰%–۴۰% of all cancers can be prevented by lifestyle and dietary procedures alone. This study was aimed to evaluate the anti-proliferative effect of Ananas comosus fruit juice on rapidly proliferating cells.Methods: The study was carried-out on rapidly proliferating seeds of Sorghum bicolor. Five groups consisting of ۲۰ seeds each were used. Groups ۱-۲ were the control and methotrexate groups respectively, while groups ۳-۵ were the test groups treated with different concentrations of A. comosus. The mean lengths (mm) of radicle emerging from the seeds were measured after ۲۴, ۴۸ and ۷۲ hours.Result: The result showed that the control S. bicolor seeds radicle had a very high growth rate throughout the study. The methotrexate treated seeds showed a significant (P<۰.۰۵) retardation in growth of radicle length when compared with control, after ۴۸ and ۷۲ hours. The inhibition rate was ۷۳.۹۳% and ۸۸.۴۵%. All doses (۴۰%-۸۰% v/v) of A. comosus fruit juice showed a remarkable inhibition of seeds radicle growth, after ۴۸ and ۷۲ hours. The percent inhibition after ۴۸ and ۷۲ hours for ۴۰% v/v was ۷۲.۳۹ and ۸۴.۳۶%, for ۶۰% v/v was ۵۳.۲۲ and ۷۲.۵۸%, while that of ۸۰% v/v was ۸۷.۳۵ and ۹۴.۷۸%, respectively. The percent inhibition at ۸۰% v/v was also higher than that produced by methotrexate throughout the study.Conclusion: The findings from the study indicate that A. comosus fruit juice has an antiproliferative effect.