Evaluation of the antiproliferative potential of Cocos nucifera juice

Introduction: The World Health Organization has predicted that the death caused by cancer may rise to a high rate of about ۱۱.۵ million in the year ۲۰۳۰. Cocos nucifera juice (Coconut water) is a known refreshing and nutritious beverage which is widely consumed traditionally for its nutritious and medicinal properties. Though assumptions traditionally suggest that it may also have an anticancer property, it is important to scientifically evaluate this property. The aim of this study is to ascertain if C. nucifera juice has an antproliferative effect. Methods: The study was carried-out on rapid proliferating seeds (Sorghum bicolor) and the mean radicle lengths (mm) was taken after ۴۸ and ۷۲ hours. Results: The control group had an unrestricted progressive proliferation throughout the study. Methotrexate elicited significant (P < ۰.۰۰۱) antiproliferative effect, with percentage inhibition of ۷۳.۹ and ۸۷.۶% after ۴۸ and ۷۲ hours. C. nucifera juice ۲۰% v/v concentration gave significant (P < ۰.۰۱) inhibitory effect of ۴۹.۹% after ۷۲ hours. C. nucifera juice ۴۰% v/v gave a significant (P < ۰.۰۱) effect of ۴۶% and a more significant (P < ۰.۰۰۱) effect of ۴۹.۷% after ۴۸ and ۷۲ hours. C. nucifera juice ۶۰% v/v had high significant (P < ۰.۰۰۱) activity after ۴۸ and ۷۲ hours, giving inhibitory effect of ۵۵.۳% and ۸۰%, respectively. C. nucifera juice and methotrexate combination had a good synergic effect, eliciting significant (P < ۰.۰۰۱) inhibitory effect of ۷۳.۴% and ۸۰% after ۴۸ and ۷۲ hours, respectively. Conclusion: The experimental results have unveiled that C. nucifera juice has a potential for eliciting antiproliferative effect.