Direct hydroxyazidation of alkenes: A viable strategy for the synthesis of β-azido alcohols

The aim of this review is to summarize the available literature on the direct hydroxyazidation of alkenes, with particular emphasize on the mechanistic features of the reactions. The metal-catalyzed reactions are discussed first. This is followed by iodine- and enzyme-catalyzed reactions. Finally, the available examples on light-mediated reactions will be covered at the end of this review.

Keywords:

Difunctionalization , hydroxyazidation , β -azido alcohols , Alkenes , carbon-carbon double bonds , biocatalysts