Evaluation of frequency polymorphism Interleukin ۱B gene in patients with peptic ulcer and chronic gastritis

Publish Year: 1394
نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:

JR_HMJ-19-6_004

تاریخ نمایه سازی: 28 بهمن 1402

Abstract:

Introduction: Helicobacter pylori is the main cause of chronic inflammation and peptic ulcer. More than half of the world population is afflicted with Helicobacter, while only ۲۰% of people show the clinical symptoms of the disease. Genes encoding the cytokines interleukin (IL)-۱B play a key role in the inflammatory responses of gastric mucus. This study aims to analyze polymorphism in the IL-۱B gene. Methods: ۱۰۷ individuals who showed the symptoms of chronic gastritis participated in the treatment group. Individuals with no symptoms were considered as the control group. IL-۱B+۳۹۵۴C/T polymorphism was analyzed through PCR-RFLP. Results: There is no association between the presence of the T allele in an IL-۱B gene whit peptic ulcer and chronic gastritis as compared with control group (OR=۰.۶۶, CI=۰.۳۴-۱.۲۷, OR=۰.۷۵, CI=۰.۳۲-۱.۱۵) respectively. Conclusion: Our results suggest that there is no association between IL-۱B+۳۹۵۴ C/T polymorphism and peptic ulcer disease and chronic inflammation.