The effect of eight weeks of high-intensity interval training with L-cysteine consumption on interleukin-۱۳ and oxidative stress of heart tissue in young rats with type ۲ diabetes

Background and aims: The purpose of this study was to investigate the effect of ۸-weeks of high-intensity interval exercise with L-cysteine (LC) consumption on interleukin (IL)-۱۳ and hydrogen peroxide of the heart tissue in young rats with type ۲ diabetes (T۲D). Methods: The statistical population of the present study consisted of young (۴-month) rats with T۲D. Ten rats were selected as a healthy group. Forty rats became diabetic. Diabetic rats were randomly divided into diabetes control, diabetics with exercise, diabetics with supplements, and diabetics with exercise and supplements. High-intensity interval exercises were performed ۳ days a week for ۸ weeks, and ۵۰۰ μmol of LC were injected daily. Results: The healthy control group had lower IL-۱۳ than the control group (P=۰.۰۰۱). There was no significant difference in IL-۱۳ between other groups. Based on the results, the diabetes control group had a higher H۲ O۲ value than the healthy control group (P=۰.۰۰۱). A significant difference was found between the exercise group+LC consumption compared to the diabetes control group, and the H۲ O۲ levels in this group were less than the diabetic control group (P=۰.۰۰۱). The exercise (P=۰.۰۱۵) and LC (P=۰.۰۰۱) groups had a lower H۲ O۲ value than the diabetes control group. Eventually, the interval exercise group+LC was also lower than the periodic exercise group (P=۰.۰۲). Conclusion: High-intensity interval training, along with the use of LC, reduced hydrogen peroxide in the heart tissue, while it had no significant impact on IL-۱۳.