Assessment of Spirometric Indices in Patients with Type ۲ Diabetes in Imam Hussein Hospital, Shahroud, Iran (۲۰۱۶-۲۰۱۷)

Background: Diabetes mellitus is the most prevalent metabolic disorder. Previous related studies have shown that, lungs are target organs in diabetic micro-angiopathy. The present study was designed to investigate the spirometric indices in patients with type ۲ diabetes referred to the outpatient clinic of Imam Hussein hospital in Shahroud, Iran.Method: This comparative study included ۵۰ patients with type ۲ diabetes and ۵۰ non-diabetic subjects who were matched in terms of weight, age, and sex, and were referred to the Diabetes clinic of Imam Hussein hospital in Shahroud, Iran. MIR SPIROLAB III spirometer was used for spirometric tests to obtain FEV۱, FVC, PEFR, and FEF ۲۵-۷۵. Decrease in these indices is determinant of pulmonary complications. Indices were compared between two groups. The relationships between some variables like glycated hemoglobin (HbA۱c) and type of their treatment with the severity of spirometric disturbances were also assessed.Result: The average age was equal to ۵۶.۳ years old (with SD of ۶.۳ years) and ۵۸.۳ years old (with SD of ۶.۳ years), respectively in non-diabetic and diabetic group. Comparison of the FEV۱, FVC, PEFR, and FEF ۲۵-۷۵ indices between diabetic and non-diabetic groups showed a significant difference (P.V<۰.۰۵). No significant difference was found in the FEV۱/FVC ratio. According to the Pearson correlation formula, there was a significant association between decreased spirometric indices and increased concentration of Hb A۱C (-.۶۳۰, -.۶۳۵ and-.۳۷۴ for FEV۱, FVC, and PEFR, respectively). There was no association between decreased concentration of FEV۱/FVC and increased HbA۱c.Conclusion: The findings of the study revealed that, there was a significant decrease in pulmonary functions in the diabetic group. Impaired pulmonary function can be detected in early stages of diabetes and studying the pulmonary function can be easily preformed. Accordingly, screening lungs function should be carried out regularly, as well as integrating in other routine examinations and screening tests.Background: Diabetes mellitus is the most prevalent metabolic disorder. Previous related studies have shown that, lungs are target organs in diabetic micro-angiopathy. The present study was designed to investigate the spirometric indices in patients with type ۲ diabetes referred to the outpatient clinic of Imam Hussein hospital in Shahroud, Iran. Method: This comparative study included ۵۰ patients with type ۲ diabetes and ۵۰ non-diabetic subjects who were matched in terms of weight, age, and sex, and were referred to the Diabetes clinic of Imam Hussein hospital in Shahroud, Iran. MIR SPIROLAB III spirometer was used for spirometric tests to obtain FEV۱, FVC, PEFR, and FEF ۲۵-۷۵. Decrease in these indices is determinant of pulmonary complications. Indices were compared between two groups. The relationships between some variables like glycated hemoglobin (HbA۱c) and type of their treatment with the severity of spirometric disturbances were also assessed. Result: The average age was equal to ۵۶.۳ years old (with SD of ۶.۳ years) and ۵۸.۳ years old (with SD of ۶.۳ years), respectively in non-diabetic and diabetic group. Comparison of the FEV۱, FVC, PEFR, and FEF ۲۵-۷۵ indices between diabetic and non-diabetic groups showed a significant difference (P.V<۰.۰۵). No significant difference was found in the FEV۱/FVC ratio. According to the Pearson correlation formula, there was a significant association between decreased spirometric indices and increased concentration of Hb A۱C (-.۶۳۰, -.۶۳۵ and-.۳۷۴ for FEV۱, FVC, and PEFR, respectively). There was no association between decreased concentration of FEV۱/FVC and increased HbA۱c. Conclusion: The findings of the study revealed that, there was a significant decrease in pulmonary functions in the diabetic group. Impaired pulmonary function can be detected in early stages of diabetes and studying the pulmonary function can be easily preformed. Accordingly, screening lungs function should be carried out regularly, as well as integrating in other routine examinations and screening tests.

Keywords:

Diabetes , Spirometry , Pulmonary disease , Imam Hussein hospital