The effect of rs۷۰۰۸۷۴۰ and rs۱۱۹۸۷۲۵۴ polymorphisms in MYBL۱ gene and its effect on male infertility in Fars province-Iran

Introduction: Infertility is defined by the failure to reach a clinical pregnancy after one year of unprotected sexual intercourse, and often ۱۵% of couples are infertile. Male factor solely and partially contributes to about ۲۰% and ۵۰% of infertilities, respectively. Both environmental and genetic factors play important roles in infertility, and the mybl۱ gene and its polymorphisms are well known in this case. This study was going to evaluate whether rs۷۰۰۸۷۴۰ and rs۱۱۹۸۷۲۵۴ polymorphisms in mybl۱ gene have a significant relationship with the risk of male infertility in Fars province or not. Materials and methods: This study involved ۱۰۰ infertile men and ۱۰۰ fertile men (control group). The Tetra-ARMS PCR and ARMS PCR techniques were used to detect mybl۱ polymorphism genotypes. Results: The results showed that rs۷۰۰۸۷۴۰ and rs۱۱۹۸۷۲۵۴ polymorphisms in mybl۱ gene did not have a significant relationship with the risk of male infertility in this population (P>۰.۰۵). However, there was a significant relationship between family history and infertility (P <۰.۰۰۱). Conclusion: This study indicated that rs۷۰۰۸۷۴۰ and rs۱۱۹۸۷۲۵۴ polymorphic loci in mybl۱ gene did not have a significant relationship with the risk of male infertility.

Keywords:

Men Infertility , mybl۱ gene , Polymorphism